replication blocking lesions (Fig. substitute DDT pathways: (1) template switching (TS) avoids the harm, i.e. the lesion is certainly bypassed by using the undamaged sister chromatid indirectly, and (2) translesion synthesis (TLS), which enables specialized DNA polymerases to reproduce across a damaged template directly. As opposed to replicative DNA polymerases, TLS polymerases absence proofreading activity … Continue reading replication blocking lesions (Fig